Dr. Karin Straathof is a research group leader at the CRUK City of London Centre and honorary consultant paediatric oncologist at Great Ormond Street Hospital.

Her research interest is T cell-based immunotherapy for childhood solid tumours. Through in-depth translational studies and preclinical testing in fateful models of paediatrics cancers she aims to develop advanced engineered T-cells which can achieve complete and durable responses for childhood solid tumours. Her work includes one of the first phase I clinical studies of CAR-T cell therapy for children with relapsed or refractory neuroblastoma. She is chief investigator for CAR T-cell clinical studies for patients with paediatric diffuse high-grade glioma, neuroblastoma and sarcomas.